5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID

Base Information

• Chemical Name: 5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID
• CAS No.: 199664-70-5
• Molecular Formula: C₁₁H₁₁FO₃
• Molecular Weight: 210.205
• Mol file: 199664-70-5.mol

Synonyms:5-(2-fluorophenyl)-5-oxopentanoic acid

Chemical Property of 5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID

Chemical Property:

• Vapor Pressure: 1.66E-06mmHg at 25°C
• Melting Point: 69 - 72°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(2-Fluorophenyl)-5-oxovalericAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.

Technology Process of 5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID

There total 1 articles about 5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

o-fluorobromobenzene (1072-85-1) + glutaric anhydride, (108-55-4) → 5-(2-fluorophenyl)-5-oxopentanoic acid (199664-70-5)

Guidance literature:

o-fluorobromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

glutaric anhydride,; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1016/j.bmcl.2009.03.148

Reference yield: 99.0%

5-(2-fluorophenyl)-5-oxopentanoic acid (199664-70-5) → 5-(2-fluorobenzoyl)dihydrofuran-2(3H)-one (1186412-85-0)

Guidance literature:

With dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; In water; ethyl acetate; at 20 ℃; for 18h;

DOI:10.1002/anie.201101522

upstream raw materials:

o-fluorobromobenzene

glutaric anhydride,

Downstream raw materials:

5-(2-fluorobenzoyl)dihydrofuran-2(3H)-one

Refernces