Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Base Information

• Chemical Name: Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
• CAS No.: 174815-58-8
• Molecular Formula: C₃₇H₅₈O₅Si
• Molecular Weight: 610.95

Synonyms:Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Chemical Property of Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

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Technology Process of Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

There total 2 articles about Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2) + Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-hydroxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (174815-57-7) → Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (174815-58-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 45 ℃; for 120h;

DOI:10.1016/0039-128X(95)00196-W

Reference yield:

Acetic acid (3S,8R,9S,10R,13S,14S,15R)-15-(4-methoxy-benzyloxy)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (174815-53-3) → Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (174815-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaBH₄ / ethyl acetate; methanol / 0.08 h / 10 °C

2: 80 percent / Et₃N, DMAP / CH₂Cl₂ / 120 h / 45 °C

With dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; ethyl acetate;

DOI:10.1016/0039-128X(95)00196-W

Reference yield: 65.0%

Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (174815-58-8) → (3S,8R,9S,10R,13S,14S,15R,17S)-17-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (174815-59-9)

Guidance literature:

With potassium hydroxide; In methanol; benzene; for 0.166667h; Heating;

DOI:10.1016/0039-128X(95)00196-W

upstream raw materials:

chlorodimethyl(1,1,2-trimethylpropyl)silane

Acetic acid (3S,8R,9S,10R,13S,14S,15R,17S)-17-hydroxy-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Acetic acid (3S,8R,9S,10R,13S,14S,15R)-15-(4-methoxy-benzyloxy)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Downstream raw materials:

(3S,8R,9S,10R,13S,14S,15R,17S)-17-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

15beta-Hydroxytestosterone

(8R,9S,10R,13S,14S,15R,17S)-17-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-15-(4-methoxy-benzyloxy)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

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