N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

Base Information

Chemical Name:N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide
CAS No.:368430-03-9
Molecular Formula:C₂₅H₂₈N₄O₂
Molecular Weight:416.523
Hs Code.:

<i>N</i>-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

Synonyms:N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

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Chemical Property of N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

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Technology Process of N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

There total 9 articles about N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 361337-20-4
benzyl imino{4-[({[4-(isopropylamino)-3-methoxy-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}methylcarbamate

: 368430-03-9
N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

Guidance literature:: With boron tribromide; In dichloromethane; at -10 ℃; for 1.5h;
DOI:10.1021/jm030233b

Reference yield:

: 361337-00-0
methyl (6-hydroxy-2-methoxy-3-nitrophenyl)acetate

: 368430-03-9
N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / CH₂Cl₂ / -10 - 20 °C

2: Pd(PPh₃)4; LiCl / dioxane / 85 °C

3: Fe; AcOH / 80 °C

4: NaHB(OAc)3 / CH₂Cl₂; tetrahydrofuran

5: NaOH / methanol / 65 °C

6: HOBt; NMM; polystyrene-bound carbodiimide / CH₂Cl₂; dimethylformamide

7: H₂ / Pd/C / methanol

8: BBr₃ / CH₂Cl₂ / -10 °C

With 4-methyl-morpholine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; polystyrene-bound carbodiimide; hydrogen; boron tribromide; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Stille coupling;
DOI:10.1016/j.bmcl.2003.08.002

Reference yield:

: 361337-03-3
methyl (4-amino-3-methoxy-1,1'-biphenyl-2-yl)acetate

: 368430-03-9
N-(4-carbamimidoyl-benzyl)-2-(3-hydroxy-4-isopropylamino-biphenyl-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaHB(OAc)3 / CH₂Cl₂; tetrahydrofuran

2: NaOH / methanol / 65 °C

3: HOBt; NMM; polystyrene-bound carbodiimide / CH₂Cl₂; dimethylformamide

4: H₂ / Pd/C / methanol

5: BBr₃ / CH₂Cl₂ / -10 °C

With 4-methyl-morpholine; sodium hydroxide; polystyrene-bound carbodiimide; hydrogen; boron tribromide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.08.002