(2S,6R)-6-propan-2-ylpiperidine-2-carboxylic Acid

Base Information

Chemical Name:(2S,6R)-6-propan-2-ylpiperidine-2-carboxylic Acid
CAS No.:158221-69-3
Molecular Formula:C₉H₁₇NO₂
Molecular Weight:171.239
Hs Code.:
DSSTox Substance ID:DTXSID30438493
Nikkaji Number:J600.783J
Wikidata:Q82254256
Mol file:158221-69-3.mol

Synonyms:158221-69-3;(2S,6R)-6-propan-2-ylpiperidine-2-carboxylic Acid;2-Piperidinecarboxylicacid,6-(1-methylethyl)-,(2S-cis)-(9CI);DTXSID30438493;2-Piperidinecarboxylicacid, 6-(1-methylethyl)-, (2S,6R)-;(2S,6R)-6-Isopropyl-2-piperidinecarboxylic acid;(2S,6R)-6-Isopropylpiperidine-2-carboxylic acid

Suppliers and Price of (2S,6R)-6-propan-2-ylpiperidine-2-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S,6R)-6-propan-2-ylpiperidine-2-carboxylic Acid

Chemical Property:

Boiling Point:288.9±33.0 °C(Predicted)
PKA:2.46±0.40(Predicted)
PSA：49.33000
Density:1.026±0.06 g/cm3(Predicted)
LogP:1.56650
XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:171.125928785
Heavy Atom Count:12
Complexity:168

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1CCCC(N1)C(=O)O
Isomeric SMILES:CC(C)[C@H]1CCC[C@H](N1)C(=O)O

Technology Process of (2S,6R)-6-propan-2-ylpiperidine-2-carboxylic Acid

There total 6 articles about (2S,6R)-6-propan-2-ylpiperidine-2-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 426827-22-7
(4S,6S,9aS)-4-phenyl-6-isopropyl-3,4,7,9a-tetrahydro-6H-pyrido[2,1-c][1,4]oxazin-1-one

: 158221-69-3,426827-26-1
(2S,6S)-6-isopropylpiperidine-2-carboxylic acid

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol;
DOI:10.1021/jo010780+

Reference yield: 74.0%

: (4R)-6-(1-Methylethyl)-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one

: 158221-69-3,426827-26-1
(2S,6R)-6-(1-Methylethyl)-2-piperidinecarboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; acetic acid; for 1h;
DOI:10.1021/jo00093a007

Reference yield:

: 288145-06-2
[2S,2(1S,3E)]-2-phenyl-2-[[1-isopropyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol

: 158221-69-3,426827-26-1
(2S,6S)-6-isopropylpiperidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / ethanol / 2 h / Heating

2.1: LiHMDS / tetrahydrofuran / 0.25 h / -45 °C

2.2: 73 percent / tetrahydrofuran / -45 - 0 °C

3.1: 78 percent / ZnCl₂ / CH₂Cl₂ / 1.5 h / 20 °C

4.1: 98 percent / H₂ / Pd(OH)2/C / ethanol

With hydrogen; zinc(II) chloride; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo010780+