tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

Base Information

Chemical Name:tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate
CAS No.:420803-56-1
Molecular Formula:C₂₄H₃₃NO₆
Molecular Weight:431.529
Hs Code.:

Synonyms:tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

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Chemical Property of tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

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Technology Process of tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

There total 9 articles about tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 86302-43-4,35000-38-5
(tert-Butoxycarbonylmethylene)triphenylphosphorane

: (4R,5R)-5-Acetyl-4-benzyl-5-methyl-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester

: 420803-56-1
tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

Guidance literature:: In chloroform; for 96h; Heating;
DOI:10.1021/ol016835b

Reference yield:

: (1-benzyl-3-methyl-2-oxo-but-3-enyl)-carbamic acid tert-butyl ester

: 420803-56-1
tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: CeCl₃ / tetrahydrofuran

2.1: NaH / tetrahydrofuran / Heating

2.2: 94 percent / tetrahydrofuran / 0 - 20 °C

3.1: O₃ / ethyl acetate / -78 °C

3.2: Me₂S / ethyl acetate / 0 °C

4.1: CHCl₃ / 24 h / Heating

With cerium(III) chloride; sodium hydride; ozone; In tetrahydrofuran; chloroform; ethyl acetate; 1.1: Grignard addition / 4.1: Wittig reaction;
DOI:10.1039/b203482d

Reference yield:

: 115186-33-9
(R)-tert-butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

: 420803-56-1
tert-butyl (2E)-3-[(4R,3S)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran

2.1: CeCl₃ / tetrahydrofuran

3.1: NaH / tetrahydrofuran / Heating

3.2: 94 percent / tetrahydrofuran / 0 - 20 °C

4.1: O₃ / ethyl acetate / -78 °C

4.2: Me₂S / ethyl acetate / 0 °C

5.1: CHCl₃ / 24 h / Heating

With cerium(III) chloride; sodium hydride; ozone; In tetrahydrofuran; chloroform; ethyl acetate; 2.1: Grignard addition / 5.1: Wittig reaction;
DOI:10.1039/b203482d