(2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

Base Information

Chemical Name:(2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester
CAS No.:206555-13-7
Molecular Formula:C₃₃H₅₃N₃O₉
Molecular Weight:635.799
Hs Code.:

(2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

Synonyms:(2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

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Chemical Property of (2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

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Technology Process of (2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

There total 11 articles about (2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 57499-17-9
N^ε-[(benzyloxy)carbonyl]-L-lysine N-methylamide

: 206555-12-6
(2S,3R)-2-tert-Butoxycarbonylmethoxy-3-isobutyl-succinic acid 1-butyl ester

: 206555-13-7
(2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
DOI:10.1021/jm970849z

Reference yield:

: 57499-17-9
N^ε-[(benzyloxy)carbonyl]-L-lysine N-methylamide

: 356548-83-9
(2R)-2-[2-butoxy-1-(2-tert-butoxy-2-oxoethoxy)-2-oxoethyl]-4-methylpentanoic acid

: (2R,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

: 206555-13-7
(2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Title compound not separated from byproducts.;
DOI:10.1021/jm010127e

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 206555-13-7
(2S,3R)-3-((S)-5-Benzyloxycarbonylamino-1-methylcarbamoyl-pentylcarbamoyl)-2-tert-butoxycarbonylmethoxy-5-methyl-hexanoic acid butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / BOP; DIEA / dimethylformamide / 20 °C

2: 100 percent / HCl / dioxane / 1 h / 20 °C

3: BOP; DIEA / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm010127e