5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide

Base Information

• Chemical Name: 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide
• CAS No.: 1426942-56-4
• Molecular Formula: C₁₃H₁₀BrFN₂O₃
• Molecular Weight: 341.136
• Mol file: 1426942-56-4.mol

Synonyms:5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide

Chemical Property of 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide

There total 3 articles about 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-bromo-2-methoxy-nicotinic acid (54916-66-4) + 2-amino-3-fluorophenol (53981-23-0) → 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide (1426942-56-4)

Guidance literature:

5-bromo-2-methoxy-nicotinic acid; With thionyl chloride; In dichloromethane; for 2h; Reflux;

2-amino-3-fluorophenol; With triethylamine; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

5-bromo-2-methoxynicotinoyl chloride (54916-68-6) + 2-amino-3-fluorophenol (53981-23-0) → 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide (1426942-56-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

5-bromo-2-methoxy-nicotinic acid (54916-66-4) → 5-bromo-N-(2-fluoro-6-hydroxyphenyl)-2-methoxynicotinamide (1426942-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 2 h / Reflux

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

upstream raw materials:

5-bromo-2-methoxy-nicotinic acid

5-bromo-2-methoxynicotinoyl chloride

2-amino-3-fluorophenol

Downstream raw materials:

5-(5-(4-fluorobenzo[d]oxazol-2-yl)-6-methoxypyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

5-(2-(1H-indazol-1-yl)pyridin-4-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide