5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine

Base Information

• Chemical Name: 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine
• CAS No.: 249509-29-3
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.315
• Mol file: 249509-29-3.mol

Synonyms:5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine

Chemical Property of 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine

There total 1 articles about 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(o-tolyl)prop-2-yn-1-ol (139416-71-0) + 2,4-dimethoxy-5-iodopyrimidine (52522-99-3) → 5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine (249509-29-3)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In triethylamine; at 55 ℃;

DOI:10.1016/S0223-5234(99)80088-9

Reference yield: 88.0%

5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine (249509-29-3) → 2,4-dimethoxy-5-(o-toluoylethynyl)pyrimidine (249509-33-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane;

DOI:10.1016/S0223-5234(99)80088-9

Reference yield:

5-[3-hydroxy-3-(o-tolyl)prop-1-ynyl]-2,4-dimethoxypyrimidine (249509-29-3) → 5-(o-toluoylethynyl)uracil

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / MnO₂ / CH₂Cl₂

2: 63 percent / aq. HCl / Heating

With hydrogenchloride; manganese(IV) oxide; In dichloromethane; 1: Oxidation / 2: demethylation;

DOI:10.1016/S0223-5234(99)80088-9

upstream raw materials:

1-(o-tolyl)prop-2-yn-1-ol

2,4-dimethoxy-5-iodopyrimidine

Downstream raw materials:

2,4-dimethoxy-5-(o-toluoylethynyl)pyrimidine