N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

Base Information

Chemical Name:N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate
CAS No.:1446235-28-4
Molecular Formula:C₂HF₃O₂*C₂₆H₂₆F₂N₄O₅S
Molecular Weight:658.603
Hs Code.:

N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

Synonyms:N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

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Chemical Property of N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

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Technology Process of N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

There total 4 articles about N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.5%

: 110-91-8,99108-56-2
morpholine

: 1622-32-8
2-Chloroethanesulfonyl chloride

: 1446235-98-8
4-[5-amino-2-(2,4-difluorophenoxy)phenyl]-6-methyl-1-tosyl-1,6-dihydro-7H-pyrrolo[2,3-c] pyridin-7-one

: 76-05-1
trifluoroacetic acid

: 1446235-28-4
N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

Guidance literature:: 2-Chloroethanesulfonyl chloride; 4-[5-amino-2-(2,4-difluorophenoxy)phenyl]-6-methyl-1-tosyl-1,6-dihydro-7H-pyrrolo[2,3-c] pyridin-7-one; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

morpholine; In methanol; at 50 ℃; for 2h;

trifluoroacetic acid; Further stages;

Reference yield:

: C₃₃H₃₂F₂N₄O₇S₂

: 76-05-1
trifluoroacetic acid

: 1446235-28-4
N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

Guidance literature:: C₃₃H₃₂F₂N₄O₇S₂; With sodium hydride; at 85 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1446235-98-8
4-[5-amino-2-(2,4-difluorophenoxy)phenyl]-6-methyl-1-tosyl-1,6-dihydro-7H-pyrrolo[2,3-c] pyridin-7-one

: 1446235-28-4
N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-2-(morpholin-4-yl)ethanesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: methanol / 2 h / 50 °C

3: sodium hydride / 2 h / 85 °C

With sodium hydride; triethylamine; In methanol; dichloromethane;