dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate

Base Information

• Chemical Name: dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate
• CAS No.: 1401466-58-7
• Molecular Formula: C₁₂H₁₃BrO₂*C₁₂H₂₃N
• Molecular Weight: 450.459
• Mol file: 1401466-58-7.mol

Synonyms:dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate

Chemical Property of dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate

There total 7 articles about dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

2-(4-bromophenyl)-2-cyclopropylpropionic acid (1401466-52-1) + N-cyclohexyl-cyclohexanamine (101-83-7) → dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate (1401466-58-7)

Guidance literature:

In tert-butyl methyl ether; at 20 - 50 ℃; for 0.5h;

Reference yield:

bromo-4-((E)-1-cyclopropyl-3-methoxy-1-methyl-3-phenylallyl)benzene → dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate (1401466-58-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ozone / dichloromethane; methanol / -78 °C / Inert atmosphere

1.2: 15 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 °C

2.2: 0 - 20 °C

3.1: potassium hydroxide; water / methanol / 60 °C

3.2: 25 °C / pH 1

4.1: tert-butyl methyl ether / 0.5 h / 20 - 50 °C

With water; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium hydroxide; In methanol; dichloromethane; tert-butyl methyl ether;

Reference yield:

2-(4-bromo-phenyl)-2-cyclopropyl-1-methoxy-prop-1-yl-hydroperoxide (1401466-57-6) → dicyclohexylammonium 2-(4-bromophenyl)-2-cyclopropylpropanoate (1401466-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 °C

1.2: 0 - 20 °C

2.1: potassium hydroxide; water / methanol / 60 °C

2.2: 25 °C / pH 1

3.1: tert-butyl methyl ether / 0.5 h / 20 - 50 °C

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium hydroxide; In methanol; dichloromethane; tert-butyl methyl ether;

upstream raw materials:

2-(4-bromophenyl)-2-cyclopropylpropionic acid

N-cyclohexyl-cyclohexanamine

2-(4-bromo-phenyl)-2-cyclopropyl-1-methoxy-prop-1-yl-hydroperoxide

3-(4-bromophenyl)-3-cyclopropyl-1-phenylbutan-1-one

Downstream raw materials:

(R)-2-(4-bromo-phenyl)-2-cyclopropylpropionitrile

2-[4-(3-{(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]-N,N-dimethylacetamide

5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine