(R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid

Base Information

Chemical Name:(R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid
CAS No.:950505-02-9
Molecular Formula:C₂₅H₂₃ClO₄
Molecular Weight:422.908
Hs Code.:

Synonyms:(R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid

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Chemical Property of (R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid

Chemical Property:

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Technology Process of (R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid

There total 3 articles about (R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₇ClO₄

: 950505-02-9
(R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid

Guidance literature:: With lithium hydroxide; water; dihydrogen peroxide; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

: 950505-99-4
C₁₃H₁₆O₄

: 950505-02-9
(R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

2: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 3 h / 50 °C

With lithium hydroxide; water; dihydrogen peroxide; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 805250-11-7
ethyl 8-hydroxy-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylate

: 950505-02-9
(R)-8-((3-(3-chloro-2-methylphenyl)-phenyl)methoxy)-2,3,4,5-tetrahydrobenzo[b]oxepine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hexane; isopropyl alcohol / Resolution of racemate

2: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

3: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 3 h / 50 °C

With lithium hydroxide; water; dihydrogen peroxide; caesium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; isopropyl alcohol;