1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea

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Chemical Name:1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea
CAS No.:1362855-07-9
Molecular Formula:C₂₄H₂₀ClN₅O₂
Molecular Weight:450.868
Hs Code.:

Synonyms:1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea

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Chemical Property of 1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea

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Technology Process of 1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea

There total 4 articles about 1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₃₁H₂₁⁽²⁾H₅ClN₅O₄S

: 1362855-07-9
1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea

Guidance literature:: With methanol; potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 4649-09-6
1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde

: 1362855-07-9
1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 1 h / 20 °C

2.1: sodium borodeuteride / d⁽⁴⁾-methanol / 1.5 h / 20 - 60 °C

3.1: phosphorus tribromide / dichloromethane / 0.5 h / 20 °C

4.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 1 h / 20 °C

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 0.17 h / 20 °C

5.2: pH 11 - 12

6.1: potassium hydroxide; methanol / tetrahydrofuran / 3 h / 20 °C

With methanol; sodium borodeuteride; phosphorus tribromide; sodium hydride; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In tetrahydrofuran; dichloromethane; d⁽⁴⁾-methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 956716-93-1
1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

: 1362855-07-9
1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[deuterio(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]indol-4-yl]urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium borodeuteride / d⁽⁴⁾-methanol / 1.5 h / 20 - 60 °C

2.1: phosphorus tribromide / dichloromethane / 0.5 h / 20 °C

3.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 0.17 h / 20 °C

4.2: pH 11 - 12

5.1: potassium hydroxide; methanol / tetrahydrofuran / 3 h / 20 °C

With methanol; sodium borodeuteride; phosphorus tribromide; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In tetrahydrofuran; dichloromethane; d⁽⁴⁾-methanol; N,N-dimethyl-formamide;