(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

Base Information

Chemical Name:(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate
CAS No.:1351669-57-2
Molecular Formula:C₄₇H₆₈N₂O₇S₂
Molecular Weight:837.198
Hs Code.:

(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

Synonyms:(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

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Chemical Property of (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

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Technology Process of (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

There total 7 articles about (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylthio)-1-hydroxypentyl)dodec-11-ynoate

: 1351669-57-2
(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

Guidance literature:: With oxone; In methanol; water; at 0 - 20 ℃; for 8h;
DOI:10.1002/anie.201102967

Reference yield:

: (1S,2R)-2-(N-benzyl-N-(mesitylsulfonyl)amino)-1-phenyl-1-propyl dodec-11ynoate

: 1351669-57-2
(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / hexane; dichloromethane / 2 h / -78 °C

1.2: 4 h / -78 - 20 °C

2.1: oxone / methanol; water / 8 h / 0 - 20 °C

With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In methanol; hexane; dichloromethane; water; 1.1: Aldol condensation / 1.2: Aldol condensation;
DOI:10.1002/anie.201102967

Reference yield:

: 7766-50-9
1-undecen-11-ylbromide

: 1351669-57-2
(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-1-5-(3-dimethylaminopropylsulfonyl)-1-hydroxypentyl)dodec-11-ynoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium / diethyl ether / 5 h / Reflux

1.2: 2 h / -40 °C

2.1: bromine / diethyl ether / 2 h / -5 °C

3.1: sodium amide / tetrahydrofuran; ammonia / 5 h / -45 - -35 °C / liquid NH₃

4.1: thionyl chloride / benzene / 3 h / Reflux

5.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

6.1: triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / hexane; dichloromethane / 2 h / -78 °C

6.2: 4 h / -78 - 20 °C

7.1: oxone / methanol; water / 8 h / 0 - 20 °C

With pyridine; thionyl chloride; bromine; sodium amide; magnesium; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ammonia; water; benzene; 6.1: Aldol condensation / 6.2: Aldol condensation;
DOI:10.1002/anie.201102967