Technology Process of R-(+)-N-propargyl-1-aminoindan besylate
There total 6 articles about R-(+)-N-propargyl-1-aminoindan besylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
toluene;
at 20 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 70 - 75 °C
2: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
3: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
4: 0.75 h / 25 - 65 °C
5: sodium hydroxide / water / 20 °C
6: ethyl acetate / 3 h / 10 - 25 °C
With
hydroxylamine hydrochloride; ammonia; hydrogen; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide;
Raney nickel;
In
methanol; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogen; ammonia / Raney nickel / methanol / 10 - 42 °C / Autoclave
2: potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide / 7 h / 40 - 70 °C
3: 0.75 h / 25 - 65 °C
4: sodium hydroxide / water / 20 °C
5: ethyl acetate / 3 h / 10 - 25 °C
With
ammonia; hydrogen; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide;
Raney nickel;
In
methanol; water; ethyl acetate;
