4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile

Base Information

Chemical Name:4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile
CAS No.:1333210-28-8
Molecular Formula:C₂₀H₂₁ClN₄O
Molecular Weight:368.866
Hs Code.:

Synonyms:4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile

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Chemical Property of 4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile

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Technology Process of 4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile

There total 5 articles about 4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356401-48-3
C₂₅H₂₉ClN₄O₃

: 1333210-28-8
4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 90685-58-8
6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide

: 1333210-28-8
4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: water / 20 - 100 °C

2: sulfuric acid / 20 - 130 °C

3: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: hydrogenchloride / dichloromethane; diethyl ether

With hydrogenchloride; di-isopropyl azodicarboxylate; sulfuric acid; water; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 533-37-9
2,3-cyclopentenopyridine

: 1333210-28-8
4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide / water; acetic acid / 70 °C

1.2: pH 9

2.1: water / 20 - 100 °C

3.1: sulfuric acid / 20 - 130 °C

4.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

5.1: hydrogenchloride / dichloromethane; diethyl ether

With hydrogenchloride; di-isopropyl azodicarboxylate; sulfuric acid; water; dihydrogen peroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid;