(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate

Base Information

• Chemical Name: (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate
• CAS No.: 1471256-49-1
• Molecular Formula: C₃₆H₃₈ClN₃O₄S
• Molecular Weight: 644.234
• Mol file: 1471256-49-1.mol

Synonyms:(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate

Chemical Property of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate

There total 12 articles about (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-5-pyridineboronic acid pinacol ester (445264-60-8) + (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)ethyl pivalate (1471256-48-0) → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate (1471256-49-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 1h; Microwave irradiation; Sealed tube; Inert atmosphere;

Reference yield:

2-methyl-4-nitrophenol (99-53-6) → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate (1471256-49-1)

Guidance literature:

Multi-step reaction with 12 steps

1.1: bromine; acetic acid / 4 h / 20 °C

2.1: triethylamine / dichloromethane / 0.33 h / -70 °C

3.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

3.2: 0.17 h / 70 °C

4.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

5.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

6.1: perchloric acid / 1.5 h / 0 - 20 °C

7.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

8.1: acetic acid / 0.5 h / 20 °C

8.2: 2 h / 20 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 110 °C / Microwave irradiation

10.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile; water / 1 h / 23 °C

11.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 4.5 h / 90 °C / Microwave irradiation; Sealed tube; Inert atmosphere

12.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 1 h / 110 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; platinum on activated charcoal; hydrogen; bromine; potassium carbonate; acetic acid; triethylamine; lithium chloride; copper(ll) bromide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

2-bromo-6-methyl-4-nitrophenol (4186-49-6) → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5'-methoxy-2,3'-bipyridin-4-yl)-5-methylbenzo-yl)ethyl pivalate (1471256-49-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: triethylamine / dichloromethane / 0.33 h / -70 °C

2.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

2.2: 0.17 h / 70 °C

3.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

4.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

5.1: perchloric acid / 1.5 h / 0 - 20 °C

6.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

7.1: acetic acid / 0.5 h / 20 °C

7.2: 2 h / 20 °C

8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 110 °C / Microwave irradiation

9.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile; water / 1 h / 23 °C

10.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 4.5 h / 90 °C / Microwave irradiation; Sealed tube; Inert atmosphere

11.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 1 h / 110 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; platinum on activated charcoal; hydrogen; potassium carbonate; acetic acid; triethylamine; lithium chloride; copper(ll) bromide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

upstream raw materials:

2-bromo-6-methyl-4-nitrophenol

2-methyl-4-nitrophenol

2-bromo-6-methyl-4-nitrophenyl trifluoromethanesulfonate

1-bromo-3-methyl-5-nitro-2-vinylbenzene

Downstream raw materials:

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5′-methoxy-2,3′-bipyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid