4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

Base Information

Chemical Name:4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide
CAS No.:1287760-95-5
Molecular Formula:C₂₇H₂₆F₃N₅O₃S
Molecular Weight:557.596
Hs Code.:

Synonyms:4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

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Chemical Property of 4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

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Technology Process of 4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

There total 13 articles about 4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287761-24-3
C₁₉H₂₂N₄O₂S

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 1287760-95-5
4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1021/jm2001376

Reference yield:

: 170569-23-0
1-(4-sulfamoylphenyl)-5-p-tolyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1287760-95-5
4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C / Molecular sieve

3: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h

5: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

7: hydrazine hydrate / methanol; dichloromethane / 20 °C / Inert atmosphere

8: triethylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 3: Horner-Wadsworth-Emmons olefination / 6: Mitsunobu reaction;
DOI:10.1021/jm2001376

Reference yield:

: 1287761-22-1
4-[3-(3-hydroxypropyl)-5-p-tolyl-pyrazol-1-yl]-benzenesulfonamide

: 1287760-95-5
4-(5-p-tolyl-3-{3-[3-(3-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2: hydrazine hydrate / methanol; dichloromethane / 20 °C / Inert atmosphere

3: triethylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1021/jm2001376