13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Base Information

• Chemical Name: 13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide
• CAS No.: 1127238-02-1
• Molecular Formula: C₃₉H₄₅N₅O₆S
• Molecular Weight: 711.882
• Mol file: 1127238-02-1.mol

Synonyms:13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Chemical Property of 13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

There total 2 articles about 13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid (1127234-98-3) + 8-oxa-3-azabicyclo[3.2.1]octane hydrochloride (54745-74-3) → 13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide (1127238-02-1)

Guidance literature:

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride; With dmap; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 78.0%

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid (1127234-98-3) + 8-oxa-3-azabicyclo [3.2.1]octane hydrochloride → 13-cyclohexyl-3-methoxy-N-[(1-methylethyl)sulfonyl]-6-[1-methyl-4-(8-oxa-3-azabicyclo[3.2.1]-oct-3-ylcarbonyl)-1H-pyrazol-5-yl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide (1127238-02-1)

Guidance literature:

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

8-oxa-3-azabicyclo [3.2.1]octane hydrochloride; With dmap; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

upstream raw materials:

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-methyl-1H-pyrazole-4-carboxylic acid

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride