methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

Base Information

Chemical Name:methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate
CAS No.:1308319-82-5
Molecular Formula:C₂₈H₂₃N₅O₃
Molecular Weight:477.522
Hs Code.:

Synonyms:methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

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Chemical Property of methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

Chemical Property:

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Technology Process of methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

There total 4 articles about methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1308319-81-4
methyl 4-(6-nitro-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

: 1308319-82-5
methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In hexafluoropropan-2-ol; at 20 ℃; for 3.5h; under 760.051 Torr;
DOI:10.1016/j.bmc.2011.03.058

Reference yield:

: 32618-85-2
6-Nitro-1H-quinazoline-2,4-dione

: 1308319-82-5
methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus pentachloride; trichlorophosphate / 6.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane; isopropyl alcohol / 4 h / 20 °C

3: hydrogenchloride / water; acetone / 10 h / Reflux

4: palladium 10% on activated carbon; hydrogen / hexafluoropropan-2-ol / 3.5 h / 20 °C / 760.05 Torr

With hydrogenchloride; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In hexafluoropropan-2-ol; dichloromethane; water; isopropyl alcohol; acetone;
DOI:10.1016/j.bmc.2011.03.058

Reference yield:

: 616-79-5
2-amino-5-nitro-benzoic acid

: 1308319-82-5
methyl 4-(6-amino-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 10 h / 150 °C

2: phosphorus pentachloride; trichlorophosphate / 6.5 h / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane; isopropyl alcohol / 4 h / 20 °C

4: hydrogenchloride / water; acetone / 10 h / Reflux

5: palladium 10% on activated carbon; hydrogen / hexafluoropropan-2-ol / 3.5 h / 20 °C / 760.05 Torr

With hydrogenchloride; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In hexafluoropropan-2-ol; dichloromethane; water; isopropyl alcohol; acetone;
DOI:10.1016/j.bmc.2011.03.058