tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate
CAS No.:1429501-41-6
Molecular Formula:C₂₁H₂₃F₃IN₃O₄
Molecular Weight:565.331
Hs Code.:

Synonyms:tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

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Chemical Property of tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

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Technology Process of tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

There total 9 articles about tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1429500-77-5
tert-butyl (2-{(4S)-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

: 1429501-41-6
tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Guidance literature:: With iodine; silver trifluoroacetate; In dichloromethane; at 5 - 20 ℃; for 2h;

Reference yield:

: 157034-03-2
dimethyl (2S)-2-(1H-pyrrol-1-yl)butanedioate

: 1429501-41-6
tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide; acetonitrile

4.1: dichloromethane / Reflux

5.1: iodine; silver trifluoroacetate / dichloromethane / 20 °C / Cooling with ice

6.1: tetrahydrofuran / 3 h / 20 °C

7.1: triphenylphosphine / dichloromethane / 20 °C

7.2: 24 h / 20 °C

8.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 2 h / 70 °C / Sealed tube; Inert atmosphere

9.1: iodine; silver trifluoroacetate / dichloromethane / 2 h / 5 - 20 °C

With lithium aluminium tetrahydride; sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; silver trifluoroacetate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1429500-55-9
(2S)-4-[(methylsulfonyl)oxy]-2-(1H-pyrrol-1-yl)butyl methanesulfonate

: 1429501-41-6
tert-butyl (2-{(4S)-6-iodo-1-oxo-7-[3-(trifluoromethoxy)phenyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide / N,N-dimethyl-formamide; acetonitrile

2.1: dichloromethane / Reflux

3.1: iodine; silver trifluoroacetate / dichloromethane / 20 °C / Cooling with ice

4.1: tetrahydrofuran / 3 h / 20 °C

5.1: triphenylphosphine / dichloromethane / 20 °C

5.2: 24 h / 20 °C

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 2 h / 70 °C / Sealed tube; Inert atmosphere

7.1: iodine; silver trifluoroacetate / dichloromethane / 2 h / 5 - 20 °C

With sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; silver trifluoroacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;