2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

Base Information

Chemical Name:2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile
CAS No.:1431978-53-8
Molecular Formula:C₁₉H₂₂BrNS
Molecular Weight:376.36
Hs Code.:

Synonyms:2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

Suppliers and Price of 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

There total 5 articles about 2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1431978-52-7
2-isopropyl-3-methyl-2-(5-(o-tolyl)thiophen-3-yl)butanenitrile

: 1431978-53-8
2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1016/j.tet.2012.11.060

Reference yield:

: 616-44-4,84928-92-7
3-Methylthiophene

: 1431978-53-8
2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / Reflux

2.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C

3.2: 20 °C

4.1: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate; Trimethylacetic acid / 20 - 140 °C / Schlenk technique

5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 60 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; lithium hexamethyldisilazane; Trimethylacetic acid; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2012.11.060

Reference yield:

: 13781-53-8
(thiophen-3-yl)acetonitrile

: 1431978-53-8
2-(2-bromo-5-(o-tolyl)thiophen-3-yl)-2-isopropyl-3-methylbutane nitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate; Trimethylacetic acid / 20 - 140 °C / Schlenk technique

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 60 °C

With N-Bromosuccinimide; palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; lithium hexamethyldisilazane; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.11.060