2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole

Base Information

Chemical Name:2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole
CAS No.:1570043-24-1
Molecular Formula:C₂₅H₂₆N₄OS
Molecular Weight:430.574
Hs Code.:

Synonyms:2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole

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Chemical Property of 2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole

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Technology Process of 2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole

There total 8 articles about 2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1570043-26-3
2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyl-4,5-dihydrooxazole

: 1570043-24-1
2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole

Guidance literature:: With manganese(IV) oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; for 48h; Reflux; Inert atmosphere;

Reference yield:

: 1570043-25-2
N-(2-hydroxy-1-phenylethyl)-4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazole-2-carboxamide

: 1570043-24-1
2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: Burgess Reagent / tetrahydrofuran / 3 h / 75 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone; manganese(IV) oxide / toluene / 48 h / Reflux; Inert atmosphere

With manganese(IV) oxide; Burgess Reagent; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; toluene;

Reference yield:

: 932-77-4
3-bromobenzyl chloride

: 1570043-24-1
2-(4-methyl-5-(3-(4-methylpiperazin-1-yl)benzyl)thiazol-2-yl)-4-phenyloxazole

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / ethanol / 20 °C / Reflux

2: copper(ll) bromide / chloroform; ethyl acetate / 2 h / Reflux

3: ethanol / Reflux

4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / Inert atmosphere; Reflux

5: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

6: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 50 °C

7: Burgess Reagent / tetrahydrofuran / 3 h / 75 °C / Inert atmosphere

8: 2,3-dicyano-5,6-dichloro-p-benzoquinone; manganese(IV) oxide / toluene / 48 h / Reflux; Inert atmosphere

With manganese(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Burgess Reagent; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(ll) bromide; lithium hydroxide; XPhos; In tetrahydrofuran; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;