3-bromo-4-chloro-7-methoxyphthalide

Base Information

• Chemical Name: 3-bromo-4-chloro-7-methoxyphthalide
• CAS No.: 913723-82-7
• Molecular Formula: C₉H₆BrClO₃
• Molecular Weight: 277.502
• Mol file: 913723-82-7.mol

Synonyms:3-bromo-4-chloro-7-methoxyphthalide

Chemical Property of 3-bromo-4-chloro-7-methoxyphthalide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4-chloro-7-methoxyphthalide

There total 1 articles about 3-bromo-4-chloro-7-methoxyphthalide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-hydroxy-6-methylbenzoate (6555-40-4) → 3-bromo-4-chloro-7-methoxyphthalide (913723-82-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / chlorine; acetic acid / 2 h / 20 °C

2: 76 percent / K₂CO₃ / acetone / 2 h / Heating

3: 69 percent / NBS; benzoyl peroxide / CCl₄ / Heating; irradiation

4: 19 percent / silver nitrate / ethanol; H₂O / 20 °C

5: 75 percent Spectr_. / NBS; benzoyl peroxide / CCl₄ / Heating; irradiation

With N-Bromosuccinimide; chlorine; potassium carbonate; silver nitrate; acetic acid; dibenzoyl peroxide; In tetrachloromethane; ethanol; water; acetone;

DOI:10.1016/j.tet.2006.07.090

Reference yield: 50.0%

3-bromo-4-chloro-7-methoxyphthalide (913723-82-7) + thiophenol (108-98-5) → 4-chloro-3-phenylthio-7-methoxyphthalide

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1016/j.tet.2006.07.090

upstream raw materials:

ethyl 2-hydroxy-6-methylbenzoate