(2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester
CAS No.:101032-72-8
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:

Synonyms:(2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester

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Technology Process of (2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester

There total 3 articles about (2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 101142-85-2,81972-26-1
-2-acetyl-3-<(1-phenylethyl)amino>-2-pentenedioic acid dimethyl ester

: 101032-72-8
(2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester

: 81972-25-0
<2S-<2α,3α,4β(R^*)>>-tetrahydro-2-methyl-6-oxo-4-<(1-phenylethyl)amino>-2H-pyran-3-carboxylic acid methyl ester hydrochloride

Guidance literature:: With phosphoric acid; hydrogen; platinum on activated charcoal; In acetic acid; at 15 - 20 ℃; for 20h; under 51714.8 Torr;
DOI:10.1021/jo00359a021

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 101032-72-8
(2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetic acid / 1.) toluene, 60 deg C, 4 h, 2.) toluene, 25 deg C

2: H₂, 85percent aq. H₃PO₄ / 5percent Pt/C / acetic acid / 20 h / 15 - 20 °C / 51714.8 Torr

With phosphoric acid; hydrogen; acetic acid; platinum on activated charcoal; In acetic acid;
DOI:10.1021/jo00359a021

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 101032-72-8
(2R,3R,4S)-2-Methyl-6-oxo-4-(1-phenyl-ethylamino)-tetrahydro-pyran-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetic acid / 1.) toluene, 60 deg C, 4 h, 2.) toluene, 25 deg C

2: H₂, 85percent aq. H₃PO₄ / 5percent Pt/C / acetic acid / 20 h / 15 - 20 °C / 51714.8 Torr

With phosphoric acid; hydrogen; acetic acid; platinum on activated charcoal; In acetic acid;
DOI:10.1021/jo00359a021