1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate
CAS No.:1366767-94-3
Molecular Formula:C₁₇H₂₀BrFN₄O₂
Molecular Weight:411.274
Hs Code.:

Synonyms:1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

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Technology Process of 1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

There total 1 articles about 1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 900805-69-8
4-bromo-2-fluorobenzohydrazide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 325775-44-8
tert-butyl 3-(aminomethyl)azetidine-1-carboxylate

: 1366767-94-3
1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

Guidance literature:: 4-bromo-2-fluorobenzohydrazide; N,N-dimethyl-formamide dimethyl acetal; In dichloromethane; at 50 ℃; for 0.5h;

tert-butyl 3-(aminomethyl)azetidine-1-carboxylate; In tetrahydrofuran; at 100 ℃;

Reference yield: 81.0%

: 1366767-94-3
1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1366767-95-4
3-(4-bromo-2-fluorophenyl)-4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazole

Guidance literature:: 1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

cyclopropanecarboxylic acid chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1366767-94-3
1,1-dimethylethyl 3-{[3-(4-bromo-2-fluorophenyl)-4H-1,2,4-triazol-4-yl]methyl}-1-azetidinecarboxylate

: 1366767-46-5
6-[4-(4-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4H-1,2,4-triazol-3-yl)-3-fluorophenyl]-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water;