(4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester

Base Information

• Chemical Name: (4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester
• CAS No.: 871326-78-2
• Molecular Formula: C₁₉H₂₇NO₅
• Molecular Weight: 349.427
• Mol file: 871326-78-2.mol

Synonyms:(4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester

Chemical Property of (4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester

There total 1 articles about (4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diethyl 2-formylaminomalonate (6326-44-9) + 4-tert-butylbenzyl chloride (19692-45-6) → (4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester (871326-78-2)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 21h; Heating;

DOI:10.1002/jlcr.918

Reference yield: 90.0%

(4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester (871326-78-2) → (4-tert-butyl-benzyl)-formamidomalonic acid (871326-79-3)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 2h; Heating;

DOI:10.1002/jlcr.918

Reference yield:

(4-tert-butyl-benzyl)-formamidomalonic acid diethyl ester (871326-78-2) → N-trifluoroacetyl-4-tert-butyl-DL-phenylalanine methyl ester (871326-83-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / NaOH / ethanol; H₂O / 2 h / Heating

2: 81 percent / petroleum ether / 3 h / Heating

3: 39 percent / PhNH₂ / 1 h / 90 - 95 °C

4: 62 percent / thionyl chloride / 48 h / 20 °C

With sodium hydroxide; thionyl chloride; aniline; In ethanol; water; Petroleum ether;

DOI:10.1002/jlcr.918

upstream raw materials:

diethyl 2-formylaminomalonate

4-tert-butylbenzyl chloride

Downstream raw materials:

(4-tert-butyl-benzyl)-formamidomalonic acid

4-tert-butyl-N-formyl-DL-phenylalanine

N-trifluoroacetyl-4-tert-butyl-DL-phenylalanine methyl ester

4'-tert-butyl-(RS)-α-phenylalanine