3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate

Base Information

• Chemical Name: 3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate
• CAS No.: 1257649-47-0
• Molecular Formula: C₂₃H₂₉NO₅
• Molecular Weight: 399.487
• Mol file: 1257649-47-0.mol

Synonyms:3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate

Chemical Property of 3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate

There total 2 articles about 3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-ethyl 3-(dimethylamino)-4-phenylbut-2-enoate (1257649-32-3) + (Z)-methyl 3-cyclohexyl-2-diazo-3-(methoxyimino)propanoate (1257649-15-2) → 3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate (1257649-47-0)

Guidance literature:

(E)-ethyl 3-(dimethylamino)-4-phenylbut-2-enoate; (Z)-methyl 3-cyclohexyl-2-diazo-3-(methoxyimino)propanoate; With bis(1,1,1,5,5,5-hexafluoro-2,4-pentadionato)copper(II) hydrate; In 1,2-dichloro-ethane; at 60 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201004073

Reference yield:

(E)-ethyl 3-(dimethylamino)-4-phenylbut-2-enoate (1257649-32-3) + (Z)-methyl 3-cyclohexyl-2-diazo-3-(methoxyimino)propanoate (1257649-15-2) → 3-ethyl 4-methyl 2-benzyl-5-cyclohexyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate (1257649-47-0) + C25H36N2O5

Guidance literature:

With bis(1,1,1,5,5,5-hexafluoro-2,4-pentadionato)copper(II) hydrate; In 1,2-dichloro-ethane; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201004073

upstream raw materials:

(E)-ethyl 3-(dimethylamino)-4-phenylbut-2-enoate

(Z)-methyl 3-cyclohexyl-2-diazo-3-(methoxyimino)propanoate