(R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

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Chemical Name:(R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea
CAS No.:1313213-91-0
Molecular Formula:C₂₀H₂₃BrN₄O₂
Molecular Weight:431.332
Hs Code.:

Synonyms:(R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

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Technology Process of (R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

There total 9 articles about (R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: N-(4-aminobenzyl)-1H-imidazole-1-carboxamide

: C₁₂H₁₅BrN₂O*C₂HF₃O₂

: 1313213-91-0
(R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01801

Reference yield: 31.0%

: 1313213-91-0
(R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

Guidance literature:

Reference yield:

: tert-butyl (4-(2-bromophenyl)-4-oxobutyl)carbamate

: 1313213-91-0
(R)-1-(4-aminobenzyl)-3-(2-(2-(2-bromophenyl)pyrrolidin-1-yl)-2-oxoethyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: sodium hydroxide / methanol / 20 °C / Inert atmosphere

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6: dichloromethane / 1 h / Inert atmosphere

7: triethylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere

With dimethylsulfide borane complex; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01801