2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester

Base Information

• Chemical Name: 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester
• CAS No.: 192644-23-8
• Molecular Formula: C₃₄H₄₃N₃O₂
• Molecular Weight: 525.734

Synonyms:2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester

Chemical Property of 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester

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Technology Process of 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester

There total 3 articles about 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(pyridin-4-yl)butyraldehyde (192643-84-8) + 2-[3-(2-amino-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester (192644-22-7) → 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester (192644-23-8)

Guidance literature:

With magnesium sulfate; In chloroform; at -10 - 0 ℃;

DOI:10.1016/S0040-4039(01)01288-6

Reference yield:

(3,5-dimethylphenyl)-(2-methylcyclopropyl)methanone (192644-21-6) → 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester (192644-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 percent / HCl / butan-1-ol / Heating

2: 75 percent / MgSO₄ / CHCl₃ / -10 - 0 °C

With hydrogenchloride; magnesium sulfate; In chloroform; butan-1-ol; 1: modified Fischer indole synthesis;

DOI:10.1016/S0040-4039(01)01288-6

Reference yield:

→ 2-{2-(3,5-dimethylphenyl)-3-[1-methyl-2-(4-pyridin-4-yl-butylamino)-ethyl]-1H-indol-5-yl}-2-methylpropionic acid ethyl ester (192644-23-8)

Guidance literature:

upstream raw materials:

4-(pyridin-4-yl)butyraldehyde

2-[3-(2-amino-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

(3,5-dimethylphenyl)-(2-methylcyclopropyl)methanone

Downstream raw materials:

2-[3-{2-[benzyloxycarbonyl-(4-pyridin-4-yl-butyl)-amino]-1-methyl-Ethyl}-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

{2-[5-(1-diethylcarbamoyl-1-methyl-ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-propyl}-(4-pyridin-4-yl-butyl)-carbamic acid benzyl ester

2-[3-{2-[benzyloxycarbonyl-(4-pyridin-4-yl-butyl)-amino]-1-methyl-ethyl}-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methyl-propionic acid

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