N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine

Base Information

Chemical Name:N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine
CAS No.:908255-35-6
Molecular Formula:C₃₉H₃₈FN₇O₆
Molecular Weight:719.772
Hs Code.:

Synonyms:N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine

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Chemical Property of N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine

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Technology Process of N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine

There total 7 articles about N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 908255-32-3
8-benzyloxyquinoline-7-carboxamide

: 908255-27-6
N,N-(di-tert-butoxycarbonyl)-8-bromo-3-(para-fluorobenzyl)adenine

: 908255-35-6
N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 90 ℃; for 4h;
DOI:10.1016/j.bmc.2006.04.011

Reference yield:

: 908255-25-4
8-bromo-3-(4-fluorobenzyl)adenine

: 908255-35-6
N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine; 4-(dimethylamino)pyridine / dimethylformamide / 2 h / 20 °C

2: 74 percent / dppf; Cs₂CO₃ / Pd₂dba3*CHCl₃ / toluene / 4 h / 90 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2006.04.011

Reference yield:

: 908255-30-1
8-benzyloxyquinoline-7-carboxylic acid benzyl ester

: 908255-35-6
N,N-(di-tert-butoxycarbonyl)-3-(4-fluorobenzyl)-8-(8-benzyloxyquinoline-7-carboxamido)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / liquid ammonia / 70 °C

2: 74 percent / dppf; Cs₂CO₃ / Pd₂dba3*CHCl₃ / toluene / 4 h / 90 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; ammonia; caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene;
DOI:10.1016/j.bmc.2006.04.011