2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide

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Chemical Name:2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide
CAS No.:1422435-47-9
Molecular Formula:C₁₇H₁₂ClF₂N₃O
Molecular Weight:347.752
Hs Code.:

Synonyms:2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide

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Chemical Property of 2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide

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Technology Process of 2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide

There total 3 articles about 2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 344287-60-1
2,2-difluoro-3-phenylcyclopropane-1-carboxylic acid

: 5418-93-9
5-chloro-1H-benzo[d]imidazol-2-amine

: 1422435-47-9
2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide

Guidance literature:: 2,2-difluoro-3-phenylcyclopropane-1-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

5-chloro-1H-benzo[d]imidazol-2-amine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 103-36-6
ethyl 3-phenyl-2-propenoate

: 1422435-47-9
2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium fluoride / toluene / 16 h / 105 °C / Inert atmosphere

1.2: 1 h / 105 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 16 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 16 h / 20 °C

With water; benzotriazol-1-ol; sodium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: ethyl 2,2-difluoro-3-phenylcyclopropanecarboxylate

: 1422435-47-9
2,2-difluoro3-phenylcyclopropanecarboxylic acid (5-chloro-1H-benzoimidazol-2-yl)amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 16 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 16 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;