1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride

Base Information

Chemical Name:1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride
CAS No.:1260491-91-5
Molecular Formula:C₂₅H₂₂F₃N₃O*ClH
Molecular Weight:473.925
Hs Code.:

Synonyms:1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride

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Chemical Property of 1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride

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Technology Process of 1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride

There total 11 articles about 1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1260494-08-3
tert-butyl 6-methyl-8-(2-oxo-4(4-trifuoromethyl)phenyl)pyridine-1(2H)-yl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate

: 1260491-91-5
1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1121-76-2
4-chloropyridine N-oxide

: 1260491-91-5
1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 0.5 h / Inert atmosphere

2: acetic anhydride / 5 h / 140 °C

3: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 18 h / 135 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; diethyl ether; methanol / 2 h / 20 °C

With hydrogenchloride; 8-quinolinol; acetic anhydride; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1260491-91-5
1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)-4((4-trifluoromethyl)phenyl)pyridin-2(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 0.5 h / Inert atmosphere

2: acetic anhydride / 5 h / 140 °C

3: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 18 h / 135 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; diethyl ether; methanol / 2 h / 20 °C

With hydrogenchloride; 8-quinolinol; acetic anhydride; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;