2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Base Information

Chemical Name:2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide
CAS No.:1048953-57-6
Molecular Formula:C₂₇H₂₁F₄N₃O₄
Molecular Weight:527.475
Hs Code.:

Synonyms:2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

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Technology Process of 2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

There total 6 articles about 2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1048953-79-2
3-(3-amino-4-fluorophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 2-(Biphenyl-4-yloxy)-propionyl chloride

: 1048953-57-6
2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Guidance literature:: With triethylamine; In toluene; at 0 - 20 ℃;
DOI:10.1002/cjoc.201180410

Reference yield:

: 1357510-83-8
3-(4-fluorophenyl-3-nitrophenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 1048953-57-6
2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; acetic acid

2: triethylamine / toluene / 0 - 20 °C

With iron; acetic acid; triethylamine; In toluene;
DOI:10.1002/cjoc.201180410

Reference yield:

: 50844-60-5
3-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidine-2,4-(1H,3H)-dione

: 1048953-57-6
2-(biphenyl-4-yloxy)-N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: sulfuric acid; nitric acid

3: iron; acetic acid

4: triethylamine / toluene / 0 - 20 °C

With sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/cjoc.201180410