3-(BROMOMETHYL)-2,4, 10-TRIOXAADAMANTANE

Base Information

• Chemical Name: 3-(BROMOMETHYL)-2,4, 10-TRIOXAADAMANTANE
• CAS No.: 157371-80-7
• Molecular Formula: C₈H₁₁BrO₃
• Molecular Weight: 235.078
• Hs Code.: 2932999099
• Mol file: 157371-80-7.mol

Synonyms:3-(BROMOMETHYL)-2,4, 10-TRIOXAADAMANTANE;3-(BROMOMETHYL)-2,4, 10-TRIOXATRICYCLO[3.3.1.1(3.7)]DECANE;BROMO(2,3, 10-TRIOXATRICYCLO[3.3.1.1(3.7)]DEC-3-YL)METHANE;3-(bromomethyl)-2,4,10-trioxatricyclo(3. 3.1.1(3)(.)(7))dec.;3-(Bromomethyl)-2,4,10-trioxaadmantane;2,4,10-Trioxatricyclo3.3.1.13,7decane, 3-(bromomethyl)-;3-(Bromomethyl)-2,4,10-trioxatricyclo[3.3.1.13.7]decane, Bromo(2,3,10-trioxatricyclo[3.3.1.13.7]dec-3-yl)methane;3-(Bromomethyl)-2,4,10-trioxaadamantane, Bromo(2,3,10-trioxatricyclo[3.3.1.13.7]dec-3-yl)methane

Chemical Property of 3-(BROMOMETHYL)-2,4, 10-TRIOXAADAMANTANE

Chemical Property:

• Vapor Pressure: 0.0143mmHg at 25°C
• Melting Point: 95-97 °C
• Refractive Index: 1.556
• Boiling Point: 266.3°C at 760 mmHg
• Flash Point: 105.5°C
• PSA: 27.69000
• Density: 1.66g/cm³
• LogP: 1.40180
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, DCM, Ethyl Acetate, Methanol

Purity/Quality:

95% ^*data from raw suppliers

3-(Bromomethyl)-2,4,10-trioxatricyclo[3.3.1.13,7]decane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-(Bromomethyl)-2,4,10-trioxatricyclo[3.3.1.13.7]decane may be used in the chemical synthesis studies.

Technology Process of 3-(BROMOMETHYL)-2,4, 10-TRIOXAADAMANTANE

There total 1 articles about 3-(BROMOMETHYL)-2,4, 10-TRIOXAADAMANTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethyl orthobromoacetate (40070-39-1) + cis,cis-1,3,5-trihydroxycyclohexane (50409-12-6,13314-30-2) → 3-(bromomethyl)-2,4,10-trioxaadamantane (157371-80-7)

Guidance literature:

With hydrogenchloride; methanol;

Reference yield:

3-(bromomethyl)-2,4,10-trioxaadamantane (157371-80-7) → 3-phenacyl-2,4,10-trioxaadamantane (157371-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0-5 deg C, 1 h; 2.) THF, hexane, 0-5 deg C, 3 h then 25 deg C, 14-18 h

2: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 24 h / 25 °C

With n-butyllithium; pyridinium chlorochromate; In dichloromethane;

DOI:10.1016/S0040-4020(01)85292-3

Reference yield:

3-(bromomethyl)-2,4,10-trioxaadamantane (157371-80-7) → 1-Phenyl-2-(2,4,10-trioxa-tricyclo[3.3.1.13,7]dec-3-yl)-ethanone oxime (157371-84-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0-5 deg C, 1 h; 2.) THF, hexane, 0-5 deg C, 3 h then 25 deg C, 14-18 h

2: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 24 h / 25 °C

3: 78 percent / NH₂OH*H₂O, pyridine / ethanol / 1 h / Heating

With pyridine; n-butyllithium; hydroxylamine; pyridinium chlorochromate; In ethanol; dichloromethane;

DOI:10.1016/S0040-4020(01)85292-3

upstream raw materials:

triethyl orthobromoacetate

cis,cis-1,3,5-trihydroxycyclohexane

Downstream raw materials:

(2,4,10-trioxaadamantylmethyl)phenylcarbinol

1-Phenyl-2-(2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-3-yl)-ethylamine

3-phenacyl-2,4,10-trioxaadamantane

1-Phenyl-2-(2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-3-yl)-ethanone oxime