(R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate

Base Information

Chemical Name:(R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate
CAS No.:1432513-74-0
Molecular Formula:C₂HF₃O₂*C₂₀H₂₀FN₅O₄S₂
Molecular Weight:591.564
Hs Code.:

Synonyms:(R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate

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Chemical Property of (R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate

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Technology Process of (R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate

There total 9 articles about (R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₈FN₅O₈S₂

: 76-05-1
trifluoroacetic acid

: 1432513-74-0
(R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate

Guidance literature:: In dichloromethane; at 18 - 25 ℃; for 0.5h;

Reference yield:

: 1432515-05-3
tert-butyl (3-(2-(hydroxymethyl)phenyl)propyl)carbamate

: 1432513-74-0
(R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodane / dichloromethane / 1.67 h / 0 °C

2: diethyl ether / 0 - 25 °C

3: ChiralTech IC column / Resolution of racemate

4: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h / 0 - 25 °C

5: dichloromethane / 0.5 h / 18 - 25 °C

With Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 1402830-48-1
tert-butyl (3-(2-formylphenyl)propyl)carbamate

: 1432513-74-0
(R)-3-(1-(2-(3-aminopropyl)phenyl)ethyl)-5-fluoro-2-oxo-N-(1,2,4-thiadiazol-5-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 0 - 25 °C

2: ChiralTech IC column / Resolution of racemate

3: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h / 0 - 25 °C

4: dichloromethane / 0.5 h / 18 - 25 °C

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane;