ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate

Base Information

Chemical Name:ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate
CAS No.:150544-87-9
Molecular Formula:C₂₃H₃₅NO₄S
Molecular Weight:421.601
Hs Code.:

Synonyms:ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate

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Chemical Property of ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate

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Technology Process of ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate

There total 1 articles about ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 150544-87-9
ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 29.8 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 15 h / -60 - 20 °C

2: 1.) sodium hexamethyldisilylamide / 1.) methanol, RT, 1 h, 2.) methanol, RT, 1 h

With sodium hexamethyldisilazane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jm00071a009

Reference yield: 100.0%

: 150544-87-9
ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate

: 150544-88-0
(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionic acid

Guidance literature:: With sodium hydroxide; In 1,2-dimethoxyethane; for 48h;
DOI:10.1021/jm00071a009

Reference yield:

: 150544-87-9
ethyl (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionate

: (4-{(S)-2-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1-trityl-1H-imidazol-4-yl)-ethylcarbamoyl]-3-phenyl-propane-1-sulfonyl}-cyclohexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h

2: 51.6 percent / oxone / methanol; H₂O / 40 h / Ambient temperature

3: 24 percent / HOBt*H₂O, N-ethylmorpholine, HBTU / acetonitrile / 2 h / Ambient temperature

With N-ethylmorpholine;; Oxone; sodium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; 1,2-dimethoxyethane; water; acetonitrile;
DOI:10.1021/jm00071a009