1-Naphthalenecarboxylicacid, 2-amino-1,2-dihydro-1-methyl-, (1R,2S)-

Base Information

Chemical Name:1-Naphthalenecarboxylicacid, 2-amino-1,2-dihydro-1-methyl-, (1R,2S)-
CAS No.:157131-00-5
Molecular Formula:C₁₂H₁₃NO₂
Molecular Weight:203.241
Hs Code.:
DSSTox Substance ID:DTXSID30455029
Mol file:157131-00-5.mol

Synonyms:157131-00-5;(1R,2S)-2-amino-1-methyl-2H-naphthalene-1-carboxylic acid;1-Naphthalenecarboxylicacid, 2-amino-1,2-dihydro-1-methyl-, (1R,2S)-;1-Naphthalenecarboxylicacid,2-amino-1,2-dihydro-1-methyl-,(1R-cis)-(9CI);(1R,2S)-2-Amino-1-methyl-1,2-dihydronaphthalene-1-carboxylic acid;DTXSID30455029;XCBLFMYHCGCXEL-CMPLNLGQSA-N

Suppliers and Price of 1-Naphthalenecarboxylicacid, 2-amino-1,2-dihydro-1-methyl-, (1R,2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-Naphthalenecarboxylicacid, 2-amino-1,2-dihydro-1-methyl-, (1R,2S)-

Chemical Property:

Boiling Point:373.8±42.0 °C(Predicted)
PKA:3.35±0.20(Predicted)
PSA：52.32000
Density:1.211±0.06 g/cm3(Predicted)
LogP:1.99760
XLogP3:-0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:203.094628657
Heavy Atom Count:15
Complexity:300

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(C=CC2=CC=CC=C21)N)C(=O)O
Isomeric SMILES:C[C@@]1([C@H](C=CC2=CC=CC=C21)N)C(=O)O

Technology Process of 1-Naphthalenecarboxylicacid, 2-amino-1,2-dihydro-1-methyl-, (1R,2S)-

There total 7 articles about 1-Naphthalenecarboxylicacid, 2-amino-1,2-dihydro-1-methyl-, (1R,2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 157130-99-9
(1R,2S)-1-((S)-4-tert-Butyl-4,5-dihydro-oxazol-2-yl)-1-methyl-1,2-dihydro-naphthalen-2-ylamine

: 157131-00-5
(1R,2S)-2-Amino-1-methyl-1,2-dihydro-naphthalene-1-carboxylic acid

Guidance literature:: With hydrogenchloride;

Reference yield:

: 132912-17-5
1-<4'-(S)-tert-butyloxazolin-2'-yl>naphthalene

: 157131-00-5
(1R,2S)-2-Amino-1-methyl-1,2-dihydro-naphthalene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: n-BuLi, HMPA / 1.) THF, hexane, -5 deg C, 45 min; -78 deg C, 1 h, 2.) -78 deg C, 20 min; -78 to -20 deg C, 3 h

2: 95 percent / conc. aq. HCl / 0.33 h

3: 82 percent / aq. NaOH, n-BuNH₂ / 12 h / 120 - 125 °C

4: 85 percent / 6 N aq. HCl / 6 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; N-butylamine;
DOI:10.1021/jo00128a016

Reference yield:

: 157130-98-8
1-[(1R,2S)-1-((S)-4-tert-Butyl-4,5-dihydro-oxazol-2-yl)-1-methyl-1,2-dihydro-naphthalen-2-yl]-piperidin-4-one

: 157131-00-5
(1R,2S)-2-Amino-1-methyl-1,2-dihydro-naphthalene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / aq. NaOH, n-BuNH₂ / 12 h / 120 - 125 °C

2: 85 percent / 6 N aq. HCl / 6 h / Heating

With hydrogenchloride; sodium hydroxide; N-butylamine;
DOI:10.1021/jo00128a016