9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

Base Information

Chemical Name:9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine
CAS No.:881915-40-8
Molecular Formula:C₄₂H₄₉N₅O₂SSi₂
Molecular Weight:744.12
Hs Code.:

Synonyms:9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

Suppliers and Price of 9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

There total 10 articles about 9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881915-01-1
tert-butyl-[(2S)-3-methylene-thietan-2-ylmethoxy]-diphenylsilane

: 881915-40-8
9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

Guidance literature:: Multi-step reaction with 8 steps

1.1: BH₃*SMe₂ / tetrahydrofuran / 2.5 h / 0 - 20 °C

1.2: 70 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 2 h

2.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3.1: NaOMe / methanol / 16 h

3.2: 1.58 g / NaBH₄ / methanol / 2 h

4.1: 90 percent / imidazole / CH₂Cl₂ / 3 h / 20 °C

5.1: mCPBA / CH₂Cl₂ / 0.5 h / -78 °C

6.1: hexamethyldisilazane / acetonitrile / 3 h / Heating

6.2: Et₃N; TMSOTf; ZnI₂ / toluene / 24 h / 0 °C

7.1: NaN₃ / dimethylformamide / 16 h / 20 °C

8.1: 0.143 g / H₂ / Pd/C / methanol / 48 h

With 1H-imidazole; sodium azide; oxalyl dichloride; dimethylsulfide borane complex; hydrogen; sodium methylate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.1: Swern oxidation;
DOI:10.1021/jm050912h

Reference yield:

: 881914-99-4
(2R,3R)-2-(tert-butyl-diphenylsilanyloxyymethyl)-thietan-3-ol

: 881915-40-8
9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

Guidance literature:: Multi-step reaction with 10 steps

1.1: 92 percent / Ac₂O; DMSO / 20 °C

2.1: titanocene dichloride / tetrahydrofuran; diethyl ether / 2 h / 20 °C

2.2: 4.12 g / diethyl ether; tetrahydrofuran / 48 h / Heating

3.1: BH₃*SMe₂ / tetrahydrofuran / 2.5 h / 0 - 20 °C

3.2: 70 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 2 h

4.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

5.1: NaOMe / methanol / 16 h

5.2: 1.58 g / NaBH₄ / methanol / 2 h

6.1: 90 percent / imidazole / CH₂Cl₂ / 3 h / 20 °C

7.1: mCPBA / CH₂Cl₂ / 0.5 h / -78 °C

8.1: hexamethyldisilazane / acetonitrile / 3 h / Heating

8.2: Et₃N; TMSOTf; ZnI₂ / toluene / 24 h / 0 °C

9.1: NaN₃ / dimethylformamide / 16 h / 20 °C

10.1: 0.143 g / H₂ / Pd/C / methanol / 48 h

With 1H-imidazole; sodium azide; oxalyl dichloride; dimethylsulfide borane complex; titanocene dichloride; hydrogen; sodium methylate; acetic anhydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Moffatt oxidation / 4.1: Swern oxidation;
DOI:10.1021/jm050912h

Reference yield:

: 887110-92-1
2-(tert-butyl-diphenyl-silanyloxymethyl)-thietan-3-one

: 881915-40-8
9-[(2S,3R,4R)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine

Guidance literature:: Multi-step reaction with 9 steps

1.1: titanocene dichloride / tetrahydrofuran; diethyl ether / 2 h / 20 °C

1.2: 4.12 g / diethyl ether; tetrahydrofuran / 48 h / Heating

2.1: BH₃*SMe₂ / tetrahydrofuran / 2.5 h / 0 - 20 °C

2.2: 70 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 2 h

3.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

4.1: NaOMe / methanol / 16 h

4.2: 1.58 g / NaBH₄ / methanol / 2 h

5.1: 90 percent / imidazole / CH₂Cl₂ / 3 h / 20 °C

6.1: mCPBA / CH₂Cl₂ / 0.5 h / -78 °C

7.1: hexamethyldisilazane / acetonitrile / 3 h / Heating

7.2: Et₃N; TMSOTf; ZnI₂ / toluene / 24 h / 0 °C

8.1: NaN₃ / dimethylformamide / 16 h / 20 °C

9.1: 0.143 g / H₂ / Pd/C / methanol / 48 h

With 1H-imidazole; sodium azide; oxalyl dichloride; dimethylsulfide borane complex; titanocene dichloride; hydrogen; sodium methylate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3.1: Swern oxidation;
DOI:10.1021/jm050912h