C₁₁H₁₀ClIN₂O

Base Information

• Chemical Name: C₁₁H₁₀ClIN₂O
• CAS No.: 1250832-32-6
• Molecular Formula: C₁₁H₁₀ClIN₂O
• Molecular Weight: 348.571
• Mol file: 1250832-32-6.mol

Synonyms:C₁₁H₁₀ClIN₂O

Chemical Property of C₁₁H₁₀ClIN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₁H₁₀ClIN₂O

There total 1 articles about C₁₁H₁₀ClIN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxodropyrimidine-5-carboxylic acid (891190-52-6) → C11H10ClIN2O (1250832-32-6)

Guidance literature:

4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxodropyrimidine-5-carboxylic acid; With sodium carbonate; sodium iodide; In methanol; water; at 20 ℃; Sonication;

With Oxone; In methanol; water; at 20 ℃; Darkness;

DOI:10.1016/j.tetlet.2010.07.093

Reference yield: 68.0%

C11H10ClIN2O (1250832-32-6) + phenylboronic acid (98-80-6) → 4-(4-chlorophenyl)-6-methyl-5-phenyl-3,4-dihydropyrimidin-2(1H)-one (1250832-36-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 70 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.093

upstream raw materials:

4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxodropyrimidine-5-carboxylic acid

Downstream raw materials:

4-(4-chlorophenyl)-6-methyl-5-phenyl-3,4-dihydropyrimidin-2(1H)-one