{3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane

Base Information

Chemical Name:{3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane
CAS No.:853995-89-8
Molecular Formula:C₂₇H₄₃BrO₅Si
Molecular Weight:555.625
Hs Code.:

Synonyms:{3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane

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Chemical Property of {3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane

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Technology Process of {3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane

There total 14 articles about {3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 853995-99-0
(2R,5S,6R)-2-[2-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-4-methyl-phenyl]-5-methyl-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-4-one

: 853995-89-8
{3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane

Guidance literature:: In tetrahydrofuran; at 60 - 63 ℃; for 24h;
DOI:10.1021/ja051420x

Reference yield: 85.0%

: 853995-99-0
(2R,5S,6R)-2-[2-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-4-methyl-phenyl]-5-methyl-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-4-one

: 853995-89-8
{3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane

Guidance literature:: In tetrahydrofuran; for 24h; Heating;
DOI:10.1021/ja060369+

Reference yield:

: 853995-97-8
2-bromo-6-hydroxy-3,5-dimethoxy-4-methyl-benzaldehyde

: 853995-89-8
{3-Bromo-4,6-dimethoxy-5-methyl-2-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-phenoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / diisopropylethylamine / dimethylformamide / 1.5 h / 20 °C

2: 77 percent / i-PrOTMS; TMSOTf / CH₂Cl₂ / -78 °C

3: 85 percent / tetrahydrofuran / 24 h / Heating

With isopropoxytrimethylsilane; trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Kurihara condensation / 3: Petasis-Tebbe reaction;
DOI:10.1021/ja060369+