(S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide
CAS No.:198268-18-7
Molecular Formula:C₁₈H₂₅F₃N₂O₂
Molecular Weight:358.404
Hs Code.:

Synonyms:(S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Suppliers and Price of (S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

There total 15 articles about (S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 198268-10-9
(S)-4-[(E)-5-(benzyloxy)pent-2-enoyl]-10,10-dimethyl-3λ⁶-thia-4-azatricyclo[5.2.1.0^1,5]decane-3,3-dione

: 198268-18-7
(S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: mol. sieves / hexane; CH₂Cl₂ / 90 h / 23 °C

1.2: 71 percent / AgOTf / CH₂Cl₂ / 1.5 h / 0 °C

2.1: 91 percent / LiAlH₄ / tetrahydrofuran / 2 h / -78 °C

3.1: 93 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

4.1: BuMgCl / tetrahydrofuran / 0.5 h / 0 - 23 °C

4.2: tetrahydrofuran / 1 h / 0 - 23 °C

5.1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

5.2: 2.34 g / HCO₂NH₄; Bu₃P / [Pd₂(dba)3] / benzene / 48 h / 23 °C

6.1: 95 percent / quinoline; H₂ / Pd/BaSO₄ / methanol / 5 h / 23 °C

7.1: Ba(OH)2; H₂O / dioxane / 2 h / 100 °C

8.1: 1.43 g / NaOH / tetrahydrofuran; H₂O / 6 h / 23 °C

9.1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

10.1: 285 mg / H₂SO₄ / dioxane / 0.25 h / 23 °C

11.1: H₂ / Raney-Ni / ethanol / 36 h / 23 °C

12.1: 119 mg / tetrahydrofuran / 2 h / 0 - 23 °C

With quinoline; barium dihydroxide; sodium hydroxide; lithium aluminium tetrahydride; molecular sieve; oxalyl dichloride; sulfuric acid; water; hydrogen; butyl magnesium bromide; dimethyl sulfoxide; triethylamine; Pd-BaSO₄; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; 1.1: Cycloaddition / 1.2: Isomerization / 2.1: Reduction / 3.1: Swern oxidation / 4.1: Metallation / 4.2: Grignard reaction / 5.1: mesylation / 5.2: Hydrogenolysis / 6.1: Catalytic hydrogenation / 7.1: Decarboxylation / 8.1: Acylation / 9.1: mesylation / 10.1: Cyclization / 11.1: Reduction / 12.1: Acylation;
DOI:10.1002/1522-2675(20000809)83:8<2007::AID-HLCA2007>3.0.CO;2-5

Reference yield:

: 198268-13-2
ethyl (4S,5R)-4-[2-(benzyloxy)ethyl]-5-formyl-4,5-dihydropyrazole-1-carboxylate

: 198268-18-7
(S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: BuMgCl / tetrahydrofuran / 0.5 h / 0 - 23 °C

1.2: tetrahydrofuran / 1 h / 0 - 23 °C

2.1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 2.34 g / HCO₂NH₄; Bu₃P / [Pd₂(dba)3] / benzene / 48 h / 23 °C

3.1: 95 percent / quinoline; H₂ / Pd/BaSO₄ / methanol / 5 h / 23 °C

4.1: Ba(OH)2; H₂O / dioxane / 2 h / 100 °C

5.1: 1.43 g / NaOH / tetrahydrofuran; H₂O / 6 h / 23 °C

6.1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

7.1: 285 mg / H₂SO₄ / dioxane / 0.25 h / 23 °C

8.1: H₂ / Raney-Ni / ethanol / 36 h / 23 °C

9.1: 119 mg / tetrahydrofuran / 2 h / 0 - 23 °C

With quinoline; barium dihydroxide; sodium hydroxide; sulfuric acid; water; hydrogen; butyl magnesium bromide; triethylamine; Pd-BaSO₄; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1.1: Metallation / 1.2: Grignard reaction / 2.1: mesylation / 2.2: Hydrogenolysis / 3.1: Catalytic hydrogenation / 4.1: Decarboxylation / 5.1: Acylation / 6.1: mesylation / 7.1: Cyclization / 8.1: Reduction / 9.1: Acylation;
DOI:10.1002/1522-2675(20000809)83:8<2007::AID-HLCA2007>3.0.CO;2-5

Reference yield:

: 198268-15-4
ethyl (4S,5S)-4-[2-(benzyloxy)ethyl]-5-{(Z)-5-[(tert-butyl)dimethylsilyloxy]but-2-enyl}-4,5-dihydropyrazole-1-carboxylate

: 198268-18-7
(S)-N-[(R)-4-(benzyloxy)-2-(piperidin-2-yl)butyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: Ba(OH)2; H₂O / dioxane / 2 h / 100 °C

2: 1.43 g / NaOH / tetrahydrofuran; H₂O / 6 h / 23 °C

3: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

4: 285 mg / H₂SO₄ / dioxane / 0.25 h / 23 °C

5: H₂ / Raney-Ni / ethanol / 36 h / 23 °C

6: 119 mg / tetrahydrofuran / 2 h / 0 - 23 °C

With barium dihydroxide; sodium hydroxide; sulfuric acid; water; hydrogen; triethylamine; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1: Decarboxylation / 2: Acylation / 3: mesylation / 4: Cyclization / 5: Reduction / 6: Acylation;
DOI:10.1002/1522-2675(20000809)83:8<2007::AID-HLCA2007>3.0.CO;2-5