2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

Base Information

Chemical Name:2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine
CAS No.:1344035-52-4
Molecular Formula:C₅₇H₅₉N₆O₈P
Molecular Weight:987.105
Hs Code.:

2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

Synonyms:2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

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Chemical Property of 2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

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Technology Process of 2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

There total 8 articles about 2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1344035-50-2
2,7-dibenzoylamino-3-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-1,8-naphthyridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1344035-52-4
2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1039/c1cc13805g

Reference yield:

: 700871-14-3
2,7-diamino-3-(2-deoxy-β-D-ribofuranosyl)-1,8-naphthyridine

: 1344035-52-4
2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: N,N-dimethyl-formamide / 9 h / 60 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Cooling

4: pyridine / 20 h / 20 °C

5: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

With pyridine; 1H-imidazole; dmap; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1cc13805g

Reference yield:

: 918408-99-8
C₂₆H₃₆N₄O₆

: 1344035-52-4
2,7-dibenzoylamino-3-{2-deoxy-3-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphino]-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl}-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 8 steps

1: trichlorophosphate / 1 h / 20 °C

2: methanol; ammonia / 13 h / 80 °C

3: methanol; ammonia / 96 h / 120 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

5: N,N-dimethyl-formamide / 9 h / 60 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Cooling

7: pyridine / 20 h / 20 °C

8: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

With pyridine; 1H-imidazole; methanol; dmap; tetrabutyl ammonium fluoride; ammonia; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1cc13805g