5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

Base Information

Chemical Name:5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester
CAS No.:144182-07-0
Molecular Formula:C₂₆H₃₃IO₅
Molecular Weight:552.45
Hs Code.:

Synonyms:5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

Suppliers and Price of 5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

There total 5 articles about 5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 144182-06-9
5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-ethynylhydroquinone 1,4-dipivaloyl ester

: 144182-07-0
5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

Guidance literature:: With morpholine; iodine; In benzene; at 45 ℃; for 0.666667h;
DOI:10.1021/ja00050a006

Reference yield:

: 144182-03-6
2,3-diiodo-5,6-dimethylhydroquinone

: 144182-07-0
5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / Pd(PPh₃)2Cl₂, CuI, diisopropylamine / benzene / 8 h / 25 °C

2: 88 percent / Pd(PPh₃)4, CuI, diisopropylamine / benzene / 19 h / Ambient temperature

3: 4.4 g / pyridine / 2 h / 60 °C

4: 1.) BF₃*Et₂O, 2.) TBAF / 1.) CH₂Cl₂, RT, 4.5 h, 2.) THF, RT, 5 min

5: 89 percent / I₂, morpholine / benzene / 0.67 h / 45 °C

With morpholine; pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; iodine; diisopropylamine; In benzene;
DOI:10.1021/ja00050a006

Reference yield:

: 144182-04-7
3-iodo-5,6-dimethyl-2-(2-(trimethylsilyl)ethynyl)hydroquinone

: 144182-07-0
5,6-dimethyl-3-(6-hydroxy-1-hexynyl)-2-(2-iodoethynyl)hydroquinone 1,4-dipivaloyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Pd(PPh₃)4, CuI, diisopropylamine / benzene / 19 h / Ambient temperature

2: 4.4 g / pyridine / 2 h / 60 °C

3: 1.) BF₃*Et₂O, 2.) TBAF / 1.) CH₂Cl₂, RT, 4.5 h, 2.) THF, RT, 5 min

4: 89 percent / I₂, morpholine / benzene / 0.67 h / 45 °C

With morpholine; pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; iodine; diisopropylamine; In benzene;
DOI:10.1021/ja00050a006