N-demethyl-N-phenylethylthebaine

Base Information

• Chemical Name: N-demethyl-N-phenylethylthebaine
• CAS No.: 144264-74-4
• Molecular Formula: C₂₆H₂₇NO₃
• Molecular Weight: 401.505
• Mol file: 144264-74-4.mol

Synonyms:N-demethyl-N-phenylethylthebaine

Chemical Property of N-demethyl-N-phenylethylthebaine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-demethyl-N-phenylethylthebaine

There total 4 articles about N-demethyl-N-phenylethylthebaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-phenyl-2-bromoethane (103-63-9) + N-demethyl-14-hydroxycodeine (2302-65-0) → N-demethyl-N-phenylethylthebaine (144264-74-4)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

DOI:10.1080/00397919208021649

Reference yield:

C24H25NO8 (144264-78-8) → N-demethyl-N-phenylethylthebaine (144264-74-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) HCl (gas), 2.) aq. NaHCO₃ / 1.) a) CH₂Cl₂, 0 deg C, 1 h, b) MeOH, reflux, 3 h

2: 73 percent / conc. ammonium hydroxide / H₂O

3: 70 percent / NaHCO₃ / dimethylformamide / 20 h / 80 °C

With hydrogenchloride; ammonium hydroxide; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

DOI:10.1080/00397919208021649

Reference yield:

6α-acetoxy-17-acetyl-4,5α-epoxy-3-methoxy-morphin-7-en-14-ol (2302-64-9) → N-demethyl-N-phenylethylthebaine (144264-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / conc. ammonium hydroxide / H₂O

2: 70 percent / NaHCO₃ / dimethylformamide / 20 h / 80 °C

With ammonium hydroxide; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

DOI:10.1080/00397919208021649

upstream raw materials:

1-phenyl-2-bromoethane

N-demethyl-14-hydroxycodeine

C₂₄H₂₅NO₈

14-hydroxycodeine diacatate

Downstream raw materials:

C₂₅H₂₇NO₄

N-demethyl-N-phenylethyl-14-hydroxycodeinone