Technology Process of (S)-4,4,5,5-tetramethyl-2-(1-p-tolylethyl)-1,3,2-dioxaborolane
There total 3 articles about (S)-4,4,5,5-tetramethyl-2-(1-p-tolylethyl)-1,3,2-dioxaborolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane;
With
copper(l) chloride; sodium t-butanolate; (1S,1S',2R,2R')-1,1'-di-tert-butyl-(2,2’)-diphospholane;
In
toluene;
for 0.166667h;
Inert atmosphere;
1-ethenyl-4-methylbenzene;
In
toluene;
at 40 ℃;
for 24h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.200902015
- Guidance literature:
-
With
ImPPA; cobalt(II) acetate;
In
diethyl ether;
at 20 ℃;
for 18h;
Schlenk technique;
Inert atmosphere;
- Guidance literature:
-
With
copper(l) chloride; sodium t-butanolate; (1S,1S',2R,2R')-1,1'-di-tert-butyl-(2,2’)-diphospholane;
In
toluene;
mixt. of CuCl, NaOtBu and tangphos in anhyd. toluene stirred in Schlenk tube under N2 for 10 min; pinacolborane added, stirred for 10 min at room temp.; styrene deriv. added; sealed; reacted at 40°C for 24 h; filtered through Celite; concd.; purified by chromy. on silica gel;
DOI:10.1002/anie.200902015
