(R)-morpholin-2-ylmethanol

Base Information

• Chemical Name: (R)-morpholin-2-ylmethanol
• CAS No.: 156925-22-3
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Hs Code.: 2934999090
• European Community (EC) Number: 801-806-2
• Mol file: 156925-22-3.mol

Synonyms:(R)-morpholin-2-ylmethanol;156925-22-3;((R)-morpholin-2-yl)methanol;[(2R)-morpholin-2-yl]methanol;(2R)-morpholin-2-ylmethanol;2-Morpholinemethanol, (2R)-;(R)-2-HYDROXYMETHYLMORPHOLINE;(R)-Morpholin-2-yl-methanol;MFCD09260717;SCHEMBL619548;VLAZLCVSFAYIIL-RXMQYKEDSA-N;AKOS006332552;AKOS015856185;s11136;AM20080410;CS-0108806;EN300-175486

Chemical Property of (R)-morpholin-2-ylmethanol

Chemical Property:

• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.441
• Boiling Point: 220.122 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 86.927 °C
• PSA: 41.49000
• Density: 1.045 g/cm³
• LogP: 0.09790
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2-Hydroxymethylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)CO
• Isomeric SMILES: C1CO[C@H](CN1)CO

Technology Process of (R)-morpholin-2-ylmethanol

There total 9 articles about (R)-morpholin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ (2R)-2-hydroxymethylmorpholine (156925-22-3)

Guidance literature:

Reference yield: 52.0%

(R)-N-benzyl-3-benzyloxymethylmorpholine (205242-60-0) → (2R)-2-hydroxymethylmorpholine (156925-22-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 55 - 60 ℃; for 4h; under 760 Torr;

DOI:10.1021/jm970806i

Reference yield: 44.0%

(R)-6-(hydroxymethyl)morpholin-3-one (919286-65-0) → (2R)-2-hydroxymethylmorpholine (156925-22-3)

Guidance literature:

(R)-6-(hydroxymethyl)morpholin-3-one; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 17h;

With potassium hydroxide; water; In tetrahydrofuran; toluene; at 0 ℃;

upstream raw materials:

(2R)-2-[(benzyloxy)methyl]morpholine

(R)-N-benzyl-3-benzyloxymethylmorpholine

(R)-4-Benzyl-6-benzyloxymethyl-morpholin-3-one

N-Benzyl-N-((R)-3-benzyloxy-2-hydroxy-propyl)-2-chloro-acetamide

Downstream raw materials:

((R)-4-Trityl-morpholin-2-yl)-methanol

(R)-N-(3,4-dichlorobenzyl)-2-hydroxymethyl-morpholine

tert-butyl (2R)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)morpholine-4-carboxylate

C₂₃H₂₈N₂O₃

Refernces

• 1、 -. "MORPHOLINO COMPOUNDS, USES AND METHODS". Page/Page column 48-49. . Retrieved 2012/12/13.
• 2、 Sawant, Rajiv T.,Waghmode, Suresh B.. "Intramolecular reductive amination strategy to the synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-2-benzylmorpholine". experimental part. p. 2010 - 2014. Retrieved 2010/04/26.