[2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine

Base Information

Chemical Name:[2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine
CAS No.:460078-46-0
Molecular Formula:C₂₇H₂₉BrN₆
Molecular Weight:517.471
Hs Code.:

[2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-<i>a</i>]pyridin-7-yl]-cyclopentyl-amine

Synonyms:[2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine

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Chemical Property of [2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine

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Technology Process of [2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine

There total 8 articles about [2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 460079-47-4
(2E)-1-[2-(3-bromophenyl)-7-(butylamino)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

: 45715-47-7
N-cyclopentyl-N'-guanidine

: 460078-46-0
[2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine

Guidance literature:: With potassium carbonate; In ethanol; Heating;
DOI:10.1016/j.bmc.2005.05.043

Reference yield:

: 460079-44-1
2-(3-bromophenyl)-7-chloropyrazolo[1,5-a]pyridine

: 460078-46-0
[2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / BF₃*Et₂O / toluene / Heating

2: 56 percent / rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate / palladium(II) acetate / toluene / 100 °C

3: 86 percent / 144 h / Heating

4: 88 percent / K₂CO₃ / ethanol / Heating

With boron trifluoride diethyl etherate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In ethanol; toluene; 2: Buchwald-Hartwig amination;
DOI:10.1016/j.bmc.2005.05.043

Reference yield:

: 460079-42-9
1-(3-bromophenyl)-2-(6-chloro-2-pyridinyl)ethanone

: 460078-46-0
[2-(3-bromo-phenyl)-3-(2-cyclopentylamino-pyrimidin-4-yl)-pyrazolo[1,5-a]pyridin-7-yl]-cyclopentyl-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / hydroxylamine hydrochloride; NaOH / methanol; H₂O / Heating

2.1: frifluoroacetic anhydride; triethylamine / 1,2-dimethoxy-ethane / 0 - 20 °C

2.2: 44 percent / iron(II) chloride / 1,2-dimethoxy-ethane / 8 h / Heating

3.1: 46 percent / BF₃*Et₂O / toluene / Heating

4.1: 56 percent / rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate / palladium(II) acetate / toluene / 100 °C

5.1: 86 percent / 144 h / Heating

6.1: 88 percent / K₂CO₃ / ethanol / Heating

With sodium hydroxide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic anhydride; palladium diacetate; In methanol; 1,2-dimethoxyethane; ethanol; water; toluene; 4.1: Buchwald-Hartwig amination;
DOI:10.1016/j.bmc.2005.05.043