8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

Base Information

Chemical Name:8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione
CAS No.:901266-43-1
Molecular Formula:C₂₀H₁₇NO₅S
Molecular Weight:383.425
Hs Code.:

8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-<i>c</i>][1,4]oxazine-3,5,8-trione

Synonyms:8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

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Chemical Property of 8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

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Technology Process of 8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

There total 10 articles about 8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-4-Benzyl-3-(2-hydroxy-3-phenylsulfanyl-propionyl)-2-oxo-oxazolidine-4-carboxylic acid

: 901266-43-1
8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

Guidance literature:: With pivaloyl chloride; triethylamine; In tetrahydrofuran; at 23 ℃;
DOI:10.1021/ol0609208

Reference yield:

: (R)-4-benzyl-2-oxo-4-oxazolidinecarboxylic acid

: 901266-43-1
8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetone

2: LiHMDS / tetrahydrofuran / -78 - 20 °C

3: TiCl₄; anisole / CH₂Cl₂ / 20 °C

4: HF / acetonitrile / 2 h / 20 °C

5: triethylamine; pivaloyl chloride / tetrahydrofuran / 23 °C

With hydrogen fluoride; pivaloyl chloride; titanium tetrachloride; methoxybenzene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1021/ol0609208

Reference yield:

: 901265-30-3
2-(tert-butyl-dimethylsilanyloxy)-3-phenylsulfanyl-propionic acid methyl ester

: 901266-43-1
8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH / methanol / 1.5 h / 20 °C

2: oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h / 20 °C

3: LiHMDS / tetrahydrofuran / -78 - 20 °C

4: TiCl₄; anisole / CH₂Cl₂ / 20 °C

5: HF / acetonitrile / 2 h / 20 °C

6: triethylamine; pivaloyl chloride / tetrahydrofuran / 23 °C

With sodium hydroxide; oxalyl dichloride; hydrogen fluoride; pivaloyl chloride; titanium tetrachloride; methoxybenzene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0609208