N-Benzyl-1-(1-methyl-1H-imidazol-2-yl)methanamine dihydrochloride

Base Information

• Chemical Name: N-Benzyl-1-(1-methyl-1H-imidazol-2-yl)methanamine dihydrochloride
• CAS No.: 474448-87-8
• Molecular Formula: C₁₂H₁₅N₃
• Molecular Weight: 201.271
• Mol file: 474448-87-8.mol

Synonyms:N-((1-methyl-1H-imidazol-2-yl)methyl)-N-(phenylmethyl)amine dihydrochloride

Chemical Property of N-Benzyl-1-(1-methyl-1H-imidazol-2-yl)methanamine dihydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Benzyl-1-(1H-imidazol-2-yl)ethanamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-1-(1-methyl-1H-imidazol-2-yl)methanamine dihydrochloride

There total 4 articles about N-Benzyl-1-(1-methyl-1H-imidazol-2-yl)methanamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-((1-methyl-1H-imidazol-2-yl)methylene)-N-(phenylmethyl)amine (1430413-12-9) → N-((1-methyl-1H-imidazol-2-yl)methyl)-N-(phenylmethyl)amine dihydrochloride (474448-87-8)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; under 15201 Torr; Autoclave;

DOI:10.1016/j.bmc.2013.01.063

Reference yield: 96.0%

2-(Aminomethyl)pyridine (3731-51-9) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → N-((1-methyl-1H-imidazol-2-yl)methyl)-N-(phenylmethyl)amine dihydrochloride (474448-87-8)

Guidance literature:

2-(Aminomethyl)pyridine; N-methyl-2-imidazolcarboxaldehyde; In methanol; at 20 ℃; for 3h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

DOI:10.1039/c3dt53636j

Reference yield:

benzylamine (100-46-9) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → N-((1-methyl-1H-imidazol-2-yl)methyl)-N-(phenylmethyl)amine dihydrochloride (474448-87-8)

Guidance literature:

upstream raw materials:

benzylamine

N-methyl-2-imidazolcarboxaldehyde

N-((1-methyl-1H-imidazol-2-yl)methylene)-N-(phenylmethyl)amine

2-(Aminomethyl)pyridine

Downstream raw materials:

N-((1-methyl-1H-imidazol-2-yl)methyl)(phenyl)methanaminedichloroplatinum(II)

Refernces

• 1、 Ferri, Nicola,Cazzaniga, Stefano,Mazzarella, Luca,Curigliano, Giuseppe,Lucchini, Giorgio,Zerla, Daniele,Gandolfi, Raffaella,Facchetti, Giorgio,Pellizzoni, Michela,Rimoldi, Isabella. "Cytotoxic effect of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in PtII complexes on human carcinoma cell lines: A comparative study with cisplatin". . p. 2379 - 2386. Retrieved 2013/05/09.
• 2、 -. "Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use". . . Retrieved 2008/06/13.