3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Base Information

Chemical Name:3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide
CAS No.:1282520-23-3
Molecular Formula:C₂₄H₂₉N₃O₄
Molecular Weight:423.512
Hs Code.:

Synonyms:3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

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Chemical Property of 3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

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Technology Process of 3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

There total 11 articles about 3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1282519-65-6
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

: 1282520-23-3
3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 12h;

Reference yield:

: 1282520-99-3
3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

: 1282520-23-3
3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane; water

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

3: sodium methylate; water / tetrahydrofuran; methanol

4: phosphorus tribromide / tetrahydrofuran

5: Reflux

6: potassium tert-butylate / tetrahydrofuran

7: hydrogen; palladium on activated charcoal / methanol

With pyridine; palladium on activated charcoal; potassium tert-butylate; water; hydrogen; sodium methylate; phosphorus tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; 6: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2012.11.018

Reference yield:

: 1282521-00-9
3-acetoxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

: 1282520-23-3
3-[2-(2-methoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

2: sodium methylate; water / tetrahydrofuran; methanol

3: phosphorus tribromide / tetrahydrofuran

4: Reflux

5: potassium tert-butylate / tetrahydrofuran

6: hydrogen; palladium on activated charcoal / methanol

With palladium on activated charcoal; potassium tert-butylate; water; hydrogen; sodium methylate; phosphorus tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 5: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2012.11.018